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cytotoxic metabolite

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N10207
    Penicitide A

    		Endogenous Metabolite Infection Cancer
    Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line .
    Penicitide A
  • HY-N6679
    (R)-10,11-Dehydrocurvularin

    		Antibiotic Cancer
    (R)-10,11-Dehydrocurvularin is a secondary metabolite isolated from Curvularia sp.. (R)-10,11-Dehydrocurvularin displays concentration-dependent cytotoxicity towards human tumor cell lines with a mean IC50 value of 1.25 µM .
    (R)-10,11-Dehydrocurvularin
  • HY-N8796
    2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone

    		Others Cancer
    2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines .
    2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone
  • HY-114917
    Aldophosphamide

    NSC 254

    		 Drug Metabolite Endogenous Metabolite Cancer
    Aldophosphamide (NSC 254) is a cyclophosphamide metabolite. Aldophosphamide is cleaved intracellularly to phosphoramide mustard, an active metabolite with direct cytotoxicity, and acrolein. Aldophosphamide has potential for cancer research .
    Aldophosphamide
  • HY-N10265
    Stephacidin B

    		Endogenous Metabolite Cancer
    Stephacidin B is a fungal metabolite. Stephacidin B shows in vitro cytotoxicity against a panel of human tumor cell lines. Stephacidin B shows the strongest cytotoxicity against testosterone-dependent prostate LNCaP cancer cells .
    Stephacidin B
  • HY-142908
    Maximiscin

    		Endogenous Metabolite Cancer
    Maximiscin, a fungal metabolite, induces DNA damage and shows selective cytotoxic activity against a subtype of triple-negative breast cancer.
    Maximiscin
  • HY-126989
    19-O-Acetylchaetoglobosin A

    		Arp2/3 Complex Cancer
    19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .
    19-O-Acetylchaetoglobosin A
  • HY-136591
    Demoxepam

    		Drug Metabolite Neurological Disease Cancer
    Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects .
    Demoxepam
  • HY-W000427
    Ethyl Orsellinate

    		Bacterial Infection Cancer
    Ethyl orsellinate is a lichen metabolite and a derivative of lecanoric acid with antiproliferative and antitumour activities . Ethyl Orsellinate is against A. salina for the cytotoxic activity with an LC50 of 495 μM .
    Ethyl Orsellinate
  • HY-143242
    Phidianidine B

    		Others Others
    Phidianidine B is a highly cytotoxic 1,2,4-oxadiazole marine metabolite. Phidianidine B is a natural product that can be isolated from a marine mollusk .
    Phidianidine B
  • HY-129558
    UK-1

    		HCV Infection Cancer
    UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities . UK-1 also inhibits HCV replication .
    UK-1
  • HY-N3102A
    (E)-p-Coumaryl alcohol

    (E)-p-Hydroxycinnamyl alcohol

    		 Others Inflammation/Immunology
    (E)-p-Coumaryl alcohol is a metabolite of coumarin that has significant cytotoxicity. (E)-p-Coumaryl alcohol can be isolated from Alpinia officinarum and Rhodiola rosea and can be used for inflammation research .
    (E)-p-Coumaryl alcohol
  • HY-N8846
    dl-Aloesol

    		Fungal Infection
    dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .
    dl-Aloesol
  • HY-129315
    Deacylketoconazole

    N-Deacetylketoconazole; R-39519

    		 Bacterial Fungal Infection
    Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte .
    Deacylketoconazole
  • HY-124414
    4'-Hydroxytamoxifen

    		Estrogen Receptor/ERR Drug Metabolite Cancer
    4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells .
    4'-Hydroxytamoxifen
  • HY-N2013
    Aristolactam I

    Aristololactam; Aristolactam
    Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage. Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway .
    Aristolactam I
  • HY-75564
    Cyclo(Ala-Gly)

    		Endogenous Metabolite Cancer
    Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC50 values range from 9.5 to 18.1 μM .
    Cyclo(Ala-Gly)
  • HY-153043
    DM-CO-(CH2)5-SMe

    		Drug Metabolite Cancer
    DM-CO-(CH2)5-SMe is an anticancer agent derived from antibody-drug conjugates (ADC) metabolite with cytotoxicity to H1703, H1975, COLO704 and Colo720E cells .
    DM-CO-(CH2)5-SMe
  • HY-111402
    Pyridomycin

    Erizomycin; NSC 246134

    		 Bacterial Antibiotic Infection
    Pyridomycin (Erizomycin) is a selective and low cytotoxic inhibitor of Mycobacterium tuberculosis that effectively targets InhA. Pyrdomycin is also an antibiotic that can be obtained from metabolites of Dactylosporangium fulvum. Pyrdomycin can be used in the study of bacterial infections such as tuberculosis .
    Pyridomycin
  • HY-148818
    S-Me-DM4
    1 Publications Verification

    		 ADC Cytotoxin Others
    S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. DM4 (HY-100503) is a microtubule-depolymerizing maytansinoid with strong cytotoxicity. DM4 can be used as an ADC Cytotoxin molecule .
    S-Me-DM4
  • HY-N8285
    Sporogen AO-1

    		Parasite Infection
    Sporogen AO-1 is a fungal metabolite originally isolated from the fungusAspergillus oryzae. Sporogen AO-1 has significant antimalarial activity againstplasmodium falciparum, with an IC50 value of 1.53 μM, and also has certain cytotoxicity .
    Sporogen AO-1
  • HY-N2040
    (20R)-Protopanaxadiol

    (20R)-Protopanaxadiol is a triterpenoid saponin metabolite of 20(R)-ginsenoside Rg3 in black ginseng. (20R)-Protopanaxadiol exhibits anti-tumor activity and cytotoxicity, and potently inhibits the growth of Helicobacter pylori .
    (20R)-Protopanaxadiol
  • HY-N10205
    Rostratin C

    		Endogenous Metabolite Cancer
    Rostratin C, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 value of 0.76μg /mL .
    Rostratin C
  • HY-16700
    PNU-159682

    		ADC Cytotoxin Topoisomerase Cancer
    PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.
    PNU-159682
  • HY-130082
    DM4-SMe

    		ADC Cytotoxin Microtubule/Tubulin Cancer
    DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM .
    DM4-SMe
  • HY-129476
    L-Canaline

    		Parasite Endogenous Metabolite Infection Cancer
    L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects .
    L-Canaline
  • HY-108263
    3-Hydroxy Midostaurin

    CGP52421

    		 FLT3 Cancer
    3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .
    3-Hydroxy Midostaurin
  • HY-N10206
    11-epi-Chaetomugilin I

    		Endogenous Metabolite Cancer
    11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .
    11-epi-Chaetomugilin I
  • HY-N10268
    3-Hydroxyterphenyllin

    NSC 299113

    		 Apoptosis Cancer
    3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .
    3-Hydroxyterphenyllin
  • HY-107818
    4-Hydroxychalcone

    		NF-κB Cardiovascular Disease Inflammation/Immunology
    4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity . 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice .
    4-Hydroxychalcone
  • HY-W272217
    Octacosane

    n-Octacosane; NSC 5549

    		 Endogenous Metabolite Bacterial Inflammation/Immunology Cancer
    Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .
    Octacosane
  • HY-125136
    Chaetominine

    (-)-Chaetominine

    		 PI3K Akt Keap1-Nrf2 Cancer
    Chaetominine is an alkaloidal metabolite. Chaetominine has cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines. Chaetominine reduces MRP1-mediated agent resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells .
    Chaetominine
  • HY-16700G
    PNU-159682

    		ADC Cytotoxin Topoisomerase Cancer
    PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.
    PNU-159682
  • HY-N12198
    Mollicellin H

    		Others Cancer
    Mollicellin H is a secondary metabolite of the fungus C. brasiliense and has a wide range of biological activities, including immunomodulation, cytotoxicity and anti-tumor effects. The growth inhibitory effects (GI50s) of Mollicellin H on human breast cancer (Bre04), human lung (Lu04) and human neuroma (N04) cell lines are 5.1 μg/mL, 6.5 μg/mL and 2.5 μg/mL respectively .
    Mollicellin H
  • HY-W272217S
    Octacosane-d58

    n-Octacosane-d58; NSC 5549-d58

    		 Bacterial Endogenous Metabolite
    Octacosane-d58 is the deuterium labeled Octacosane[1]. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[2][3][4].
    Octacosane-d58
  • HY-116364
    AZT triphosphate

    3'-Azido-3'-deoxythymidine-5'-triphosphate

    		 HIV DNA/RNA Synthesis HBV Reactive Oxygen Species Apoptosis Infection
    AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate also inhibits the DNA polymerase of HBV. AZT triphosphate activates the mitochondria-mediated apoptosis pathway .
    AZT triphosphate
  • HY-116364A
    AZT triphosphate TEA

    3'-Azido-3'-deoxythymidine-5'-triphosphate TEA

    		 HIV DNA/RNA Synthesis HBV Reactive Oxygen Species Apoptosis Infection
    AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) TEA is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TEA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TEA also inhibits the DNA polymerase of HBV. AZT triphosphate TEA activates the mitochondria-mediated apoptosis pathway .
    AZT triphosphate TEA
  • HY-116364B
    AZT triphosphate tetraammonium

    3'-Azido-3'-deoxythymidine-5'-triphosphate tetraammonium

    		 HIV DNA/RNA Synthesis HBV Reactive Oxygen Species Apoptosis Infection
    AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV. AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway .
    AZT triphosphate tetraammonium
  • HY-N12165
    1,3,5,6-Tetrahydroxy-8-methylxanthone

    		Others Others
    1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .
    1,3,5,6-Tetrahydroxy-8-methylxanthone

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